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. 2019 Apr 16;6:46. doi: 10.3389/fnut.2019.00046

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Copyright © 2019 St-Pierre, Vandenberghe, Lowry, Fortier, Castellano, Wagner and Cunnane.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma octanoate (A), acetoacetate (B), decanoate (C), β-hydroxybutyrate (D), dodecanoate (E), and total ketones (F) throughout the 8 h metabolic study day during which two 20 ml doses of the following test substances were consumed: tricaprylin (C8,×), tricaprin(C10,□), medium chain triglyceride (C8C10, ▾), or trilaurin (C12, ■). Plasma acetoacetate, β-hydroxybutyrate, and total ketones values were normalized to T0, and control day values were subtracted prior to graphing the results. Plasma octanoate, decanoate, and dodecanoate were extracted from plasma total lipids. The white arrow () indicates the time at which breakfast plus the dose of test oil was consumed; the black arrow () indicates when the dose of test oil alone was consumed at midday (without a meal). Data are the mean ± SEM for n = 8–9 participants/point.

Inline graphic — Plasma octanoate (A), acetoacetate (B), decanoate (C), β-hydroxybutyrate (D), dodecanoate (E), and total ketones (F) throughout the 8 h metabolic study day during which two 20 ml doses of the following test substances were consumed: tricaprylin (C8,×), tricaprin(C10,□), medium chain triglyceride (C8C10, ▾), or trilaurin (C12, ■). Plasma acetoacetate, β-hydroxybutyrate, and total ketones values were normalized to T0, and control day values were subtracted prior to graphing the results. Plasma octanoate, decanoate, and dodecanoate were extracted from plasma total lipids. The white arrow () indicates the time at which breakfast plus the dose of test oil was consumed; the black arrow () indicates when the dose of test oil alone was consumed at midday (without a meal). Data are the mean ± SEM for n = 8–9 participants/point.