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. 2019 Mar 22;10(24):2355–2368. doi: 10.18632/oncotarget.26760

Figure 3. Glycolysis and mitochondrial stress tests of compounds 3 and 9.

Figure 3

(A–C) represent the parameters from glycolysis stress test: (A) glycolysis, (B) glycolytic capacity, and (C) glycolytic reserve of compounds at 30 μM concentration in WiDr and MDA-MB-231 cells. (D–G) represent the parameters from mitochondrial stress test: (D) maximal respiration, (E) ATP production, (F) proton leak, and (G) spare respiratory capacity in WiDr and MDA-MB-231 cells. The ECAR and OCR values of were calculated using wave software. The average + SEM values of at least three independent experimental values were calculated. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.