Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 19;10(23):2237–2251. doi: 10.18632/oncotarget.26787

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2019 Halaban et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

The figure shows SAB298 and UM-164 common inhibition of SFK and PI3K activities (_┴) that lead to growth arrest but opposite effects on MITF (down- versus up-regulation) that may contribute to long term response to the drug, such as development of resistance in the presence of high levels of MITF.