Figure 3. Synergistic Inhibition of BRAF^V600E Melanoma Cell Proliferation by Treatment with SFK and MEK Inhibitors.

Cell proliferation of YUSIK, 501 mel and YUROB melanoma cell lines (A, B and C, respectively) in response to SAB298 (blue), AZD6244 (red), and AZD6244 plus SAB298 (green). SAB298 was added to AZD6244 at 0.15 µM (YUSIK), or 0.4 µM (501 mel and YUROB). The IC₅₀ for each drug alone and in combination are indicated in the legend for each cell line.