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. 2019 Mar 19;10(23):2237–2251. doi: 10.18632/oncotarget.26787

Figure 8. SAB298 inactivates PP2A, SHP2 via ERBB2 inhibition.

Figure 8

(A) SAB298 increases the levels of inactivated PP2A (pPP2A Y307) in YUSIK and YUSIV melanoma cells in a fashion similar to okadaic acid (Okadaic a). Active (unphosphorylated) PP2A is not dependent on the presence of pY416 SFK. Panels B and C show SHP2 inactivation by SAB298 in YUSIK, YUROB and YUSOC, but not YUGASP melanoma cells (pSHP2 Y542). Suppression of SHP2 is associated with SAB298 induced inactivation of ERBB2 (pERBB2 Y1196) (C, D).