Treatment class |
Treatment modality |
Included studies |
Other studies |
'Doing nothing' |
Awaiting natural resolution |
— |
Olsen 2015; Takemura 1983
|
Placebo |
Antony 2001; Eichenfield 2005; Manchanda 1997b; Paller 2005a; Paller 2005b
|
— |
Surgical treatments |
Cryotherapy |
Al‐Mutairi 2010 |
Barton 2002; Caballero 1996; Salmanpour 2006
|
Curettage |
Hanna 2006; Machado 2010
|
de Waard 1990; Simonart 2008
|
Curettage with punch |
— |
Quan 2000 |
Electric cauterisation |
— |
He 2001 |
Physical expression (squeezing) |
— |
Weller 1999 |
Pricking |
— |
Wishart 1903 |
Pulsed dye laser |
— |
Hammes 2001 |
Topical treatments |
Acidified nitrite |
Ormerod 1999 |
Gräfe 2000 |
Adapalene |
— |
Scheinfeld 2007 |
Australian lemon myrtle oil |
Burke 2004 |
— |
Benzoyl peroxide |
Saryazdi 2004 |
— |
Bromogeramine |
— |
He 2001 |
Cantharidin |
Coloe Dosal 2014; Hanna 2006
|
Funt 1961; Funt 1979; Ross 2004; Silverberg 2000
|
Cidofovir |
— |
Davies 1999; Toro 2000; Zabawski 1999
|
Diphencyprone |
— |
Kang 2005; Kyu 1993
|
Griseofulvin |
— |
Salmanpour 2006 |
Honey |
— |
Holt 2015 |
Hydrogen peroxide cream |
— |
Bigardi 2003; Semkova 2014
|
Hyperthermia |
— |
Gao 2016 |
Imiquimod |
Al‐Mutairi 2010; Eichenfield 2005; Hanna 2006; Paller 2005a; Paller 2005b; Seo 2010; Theos 2004
|
Arican 2006; Barba 2001; Bayerl 2003; Hengge 2003; Lim 2003; Liota 2000; Metkar 2008; Skinner 2000; Skinner 2002; Syed 1998
|
Iodine |
Markum 2012 |
— |
Iodine combined with tea tree oil |
Markum 2012 |
— |
Milkweed |
— |
Behl 1970 |
Povidone iodine plus salicylic acid |
Markum 2012; Ohkuma 1990
|
— |
Phenol |
Leslie 2005 |
Weller 1999 |
Podophyllotoxin (HIV patients) |
— |
Markos 2001; Syed 1994; Teilla‐Hamel 1996
|
Potassium hydroxide |
Bazza 2007; Machado 2010; Seo 2010; Short 2006; Uçmak 2013
|
Metkar 2008; Romiti 1999; Romiti 2000
|
Retinoic acid |
— |
Hund 1975 |
Salicylic acid |
Hanna 2006; Leslie 2005; Ohkuma 1990
|
— |
Salicylic acid combined with lactic acid |
Machado 2010 |
— |
Salicylic acid combined with sodium nitrite |
Ormerod 1999 |
— |
Silver nitrate |
— |
Niizeki 1999 |
Tea tree oil |
Markum 2012 |
— |
Tretinoin |
Saryazdi 2004 |
— |
Yellow oxide of mercury |
— |
Davis 1896 |
Systemic treatments |
Cimetidine |
Antony 2001 |
Cunningham 1998; Dohil 1996; Sharma 1998; Yasher 1999
|
Calcarea carbonica (homeopathy) |
Manchanda 1997b |
Manchanda 1997a |
Griseofulvin |
— |
Singh 1977 |
Combinations of above |
Potassium iodide followed by X‐rays |
— |
Cope 1915 |