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. 2017 May 17;2017(5):CD004767. doi: 10.1002/14651858.CD004767.pub4

Al‐Mutairi 2010.

Methods Randomised controlled trial
Participants 74 children 2 to 12 years of age, hospital outpatient clinic in Kuwait
Interventions Imiquimod 5% for up to 16 weeks versus cryospray for up to 2 weeks
Outcomes Cure at 3, 6, 12, and 16 weeks; cosmetic outcome; adverse effects
Notes Funding: not mentioned
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No details except 'randomly assigned'
Allocation concealment (selection bias) Unclear risk No details
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Probably not blinded: cream versus cryospray
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Probably not blinded: cream versus cryospray
Incomplete outcome data (attrition bias) 
 Short‐term outcomes (up to 3 months) Low risk All participants had complete follow‐up.
Incomplete outcome data (attrition bias) 
 Medium‐ and long‐term outcomes (3‐6 months and longer) Low risk All participants had complete follow‐up.
Selective reporting (reporting bias) Unclear risk Protocol not available
Other bias Unclear risk No baseline imbalance for gender, MC area, morphology, MC location, or baseline lesion count, but no data on compliance