| Methods |
Randomised controlled trial |
| Participants |
74 children 2 to 12 years of age, hospital outpatient clinic in Kuwait |
| Interventions |
Imiquimod 5% for up to 16 weeks versus cryospray for up to 2 weeks |
| Outcomes |
Cure at 3, 6, 12, and 16 weeks; cosmetic outcome; adverse effects |
| Notes |
Funding: not mentioned |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
No details except 'randomly assigned' |
| Allocation concealment (selection bias) |
Unclear risk |
No details |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
Probably not blinded: cream versus cryospray |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
Probably not blinded: cream versus cryospray |
| Incomplete outcome data (attrition bias)
Short‐term outcomes (up to 3 months) |
Low risk |
All participants had complete follow‐up. |
| Incomplete outcome data (attrition bias)
Medium‐ and long‐term outcomes (3‐6 months and longer) |
Low risk |
All participants had complete follow‐up. |
| Selective reporting (reporting bias) |
Unclear risk |
Protocol not available |
| Other bias |
Unclear risk |
No baseline imbalance for gender, MC area, morphology, MC location, or baseline lesion count, but no data on compliance |
