Hanna 2006.

Methods	Randomised controlled trial
Participants	124 children, 1 to 16 years of age, dermatology clinic, Montreal, Canada M/F: 57/67
Interventions	4 arms: curettage, topical cantharidin 0.7%, topical salicylic acid 16.7% + lactic acid 16.7%, topical imiquimod cream 5%
Outcomes	Number of visits required. Intervals between study visits not reported, so outcome data not suitable for inclusion.
Notes	Total number of participants unclear. Percentage of group 3 in Table 1 does not correspond to number mentioned in text. Funding: 3 pharmaceutical companies provided treatments for free.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "The randomizations list was generated by specialized computer software (PC‐PLAN, Dalal, 1996)"
Allocation concealment (selection bias)	Unclear risk	Quote: "The randomizations list was generated by specialized computer software (PC‐PLAN, Dalal, 1996)." Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	High risk	Quote: "This is not a double‐blind study." Physical versus topical treatment
Blinding of outcome assessment (detection bias) All outcomes	High risk	Quote: "This is not a double‐blind study." Physical versus topical treatment
Incomplete outcome data (attrition bias) Short‐term outcomes (up to 3 months)	Unclear risk	Not reported
Incomplete outcome data (attrition bias) Medium‐ and long‐term outcomes (3‐6 months and longer)	Unclear risk	Not reported
Selective reporting (reporting bias)	Unclear risk	Unclear
Other bias	Unclear risk	No baseline comparison. No compliance data