Summary of findings 4. Coasting versus follicle stimulating hormone administration at time of hCG for preventing ovarian hyperstimulation syndrome.
| Coasting versus follicle stimulating hormone (FSH) administration at time of hCG trigger in preventing ovarian hyperstimulation syndrome (OHSS) | ||||||
| Population: Women undergoing assisted reproduction Setting: Assisted reproduction clinics Intervention: Coasting Comparison: FSH co‐trigger with hCG administration | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with FSH co‐trigger with hCG administration | Risk with Coasting | |||||
| OHSS | Not estimable | Not estimable | OR 43.74 (2.54 to 754.58) | 102 (1 RCT) | ⊕⊝⊝⊝ VERY LOW1,2 | |
| Live birth | No data available | |||||
| Clinical Pregnancy | 510 per 1000 | 489 per 1000 (309 to 676) | OR 0.92 (0.43 to 2.01) | 102 (1 RCT) | ⊕⊕⊝⊝1,3 LOW | |
| Multiple pregnancy | No data available | |||||
| Miscarriage | No data available | |||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the mean risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio; hCG: human chorionic gonadotrophin | ||||||
| GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1 Downgraded one level due to serious risk of bias: method of sequence generation not reported, lack of blinding
2 Downgraded two levels due to very serious imprecision: only 15 events, all in one arm.
3 Downgraded one level due to serious imprecision: very wide confidence intervals