Summary of findings 5. Coasting compared to cabergoline for preventing ovarian hyperstimulation syndrome.

Coasting compared to cabergoline for preventing ovarian hyperstimulation syndrome (OHSS)
Population: Women undergoing assisted reproduction Setting: Assisted reproduction clinics Intervention: Coasting Comparison: Cabergoline
Outcomes	Anticipated absolute effects* (95% CI)		Relative effect (95% CI)	№ of participants (studies)	Quality of the evidence (GRADE)	Comments
	Risk with cabergoline	Risk with Coasting
OHSS	100 per 1000	180 per 1000 (71 to 387)	OR 1.98 (0.69 to 5.68)	120 (2 RCTs)	⊕⊝⊝⊝1,2 VERY LOW
Live birth	Not reported
Clinical pregnancy rate	367 per 1000	180 per 1000 (85 to 338)	OR 0.38 (0.16 to 0.88)	120 (2 RCTs)	⊕⊕⊝⊝1 VERY LOW
Multiple pregnancy	Not reported
Miscarriage	Not reported
*The risk in the intervention group (and its 95% confidence interval) is based on the mean risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio
GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect

1 Downgraded two levels due to very serious risk of bias: one study did not clearly define method, method of sequence generation not reported, lack of blinding

² Downgraded one level due to serious imprecision: very few events and/or wide confidence interval.