Aflatoonian 2006.
Methods | Randomised controlled trial | |
Participants | Iran and UK study 52 women undergoing IVF treatment cycles at high risk for developing OHSS (> 20 follicles in both ovaries, serum estradiol = E2 > 3000 pg/ml). |
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Interventions | Induction of ovulation with long protocol beginning with pituitary desensitisation with subcutaneous buserelin and followed by hMG 3 amp from day 2. On day 9 randomised to: Coasting group (N = 27) IVF/ICSI defined as presence of > 10 follicles per ovary with a leading follicle > 17 mm and E2 > 3000 pg/ml (maximum 3 days). Then 10000 units hCG administered and oocyte retrieval 34 to 36 hours later. Aspiration follicle group (N = 26) had > 15 follicles 15 to 16mm in each ovary and E2 > 3000 pg/ml. Unilateral aspiration follicular aspiration performed before hCG administration. Oocyte retrieval performed 34 to 36 hours later in the other ovary. Embryo transfer was done 2 days later in both groups. |
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Outcomes | Number of follicles, number of oocytes, pregnancy rate, OHSS. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | 'randomized controlled trial' |
Allocation concealment (selection bias) | Unclear risk | No details |
Blinding (performance bias and detection bias) All outcomes | High risk | No blinding |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No details |
Selective reporting (reporting bias) | Unclear risk | Outcomes not mentioned in methods ‐ this was a conference abstract. Did not report live birth. |