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. 2017 May 23;2017(5):CD002811. doi: 10.1002/14651858.CD002811.pub4

Aflatoonian 2006.

Methods Randomised controlled trial
Participants Iran and UK study
52 women undergoing IVF treatment cycles at high risk for developing OHSS (> 20 follicles in both ovaries, serum estradiol = E2 > 3000 pg/ml).
Interventions Induction of ovulation with long protocol beginning with pituitary desensitisation with subcutaneous buserelin and followed by hMG 3 amp from day 2.
On day 9 randomised to:
Coasting group (N = 27) IVF/ICSI defined as presence of > 10 follicles per ovary with a leading follicle > 17 mm and E2 > 3000 pg/ml (maximum 3 days). Then 10000 units hCG administered and oocyte retrieval 34 to 36 hours later.
Aspiration follicle group (N = 26) had > 15 follicles 15 to 16mm in each ovary and E2 > 3000 pg/ml. Unilateral aspiration follicular aspiration performed before hCG administration. Oocyte retrieval performed 34 to 36 hours later in the other ovary.
Embryo transfer was done 2 days later in both groups.
Outcomes Number of follicles, number of oocytes, pregnancy rate, OHSS.
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk 'randomized controlled trial'
Allocation concealment (selection bias) Unclear risk No details
Blinding (performance bias and detection bias) 
 All outcomes High risk No blinding
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk No details
Selective reporting (reporting bias) Unclear risk Outcomes not mentioned in methods ‐ this was a conference abstract. Did not report live birth.