1. Summary of included studies.
| Study | Dates | Complete revascularisation (staged vs 1 time) | Intervention criteria in non‐culprit vessel | Mean follow‐up (years) | Description multi‐vessel disease | Country | Number of centres |
| CvLPRIT 2015 | May 2011 to May 2013 | At index procedure or before discharge. 65% of participants in invasive group had at index procedure. | > 70% diameter stenosis in 1 plane or > 50% in 2 planes. | 2.5 | Culprit vessel plus ≥ 1 non‐infarct‐related epicardial artery with ≥ 1 lesion deemed angiographically significant (> 70% stenosis in 1 plane or > 50% in 2 planes). | UK | 7 |
| Dambrink and Ghani 2010 | June 2004 to February 2007. | Staged 7.5 days after P‐PCI. | FFR < 0.75 and in stenosis > 90%, PCI was performed without FFR measurement. PCI was with BMS or DES. | 3 | ≥ 1 significant stenosis (> 50% stenosis in ≥ 1 view) in ≥ 2 major epicardial coronary arteries, or the combination of a side branch and a main epicardial vessel provided that they supplied different territories. | The Netherlands | 1 |
| DANAMI‐3‐PRIMULTI 2015 | March 2011 to February 2014 | Staged 2 days after P‐PCI. | FFR < 0.8 and those > 90% stenotic arteries visually. | 2.2 | Significant stenosis (> 50% stenosis visually in arteries > 2 mm diameter) in ≥ 1 of the non‐culprit epicardial coronary arteries or their major side branches in addition to the infarct‐related artery. | Denmark | 2 |
| Estevez Loureiro 2014 | 2010 to 2013 | Staged. | Complete. Criteria not described in study. | 1 | NR. | Spain | NR |
| HELP AMI 2004 | NR | Index procedure. | Not described. | 1 | NR. | Not described | NR |
| Politi 2009 | January 2003 to December 2007 | At index procedure or staged mean 56 days after P‐PCI. 50% participants of complete revascularisation had at intervention of the non‐culprit lesions at index procedure. | > 70% diameter stenosis. | 2.5 | > 70% diameter stenosis of ≥ 2 epicardial coronary arteries or their major branches by visual estimation. | Not described | NR |
| PRAGUE‐13 2015 | September 2008 to December 2014 | Staged between 3 and 40 days after P‐PCI. | > 70% stenosis of non‐culprit coronary artery. | 3 | ≥ 1 vessel, beside the culprit vessel, with significant stenosis (> 70% stenosis). | Czech Republic | 6 |
| PRAMI 2013 | April 2008 to January 2013 | At index procedure. | Stenosis ≥ 50%. | 2 | The presence of stenosis ≥ 50% in ≥ 1 coronary artery other than the culprit vessel. | UK | 5 |
| Zhang 2015 | January 2009 to June 2012 | Staged between 7 and 10 days after P‐PCI. | 75% to 90%. | 2 | Non‐culprit vessel with significant stenosis (75% to 90% stenosis). | China | NR |
BMS: bare‐metal stent; DES: drug‐eluting stent; FFR: fractional flow reserve; NR: not reported in the article; PCI: percutaneous coronary intervention; P‐PCI: primary percutaneous coronary intervention.