Comparison 1. Primary outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Long‐term all‐cause mortality	8		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Long‐term all‐cause mortality	8	2417	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.58, 1.11]
2 Long‐term cardiovascular mortality	6		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Long‐term cardiovascular mortality	6	2229	Risk Ratio (M‐H, Fixed, 95% CI)	0.50 [0.32, 0.79]
3 Long‐term non‐fatal myocardial infarction	6		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Long‐term non‐fatal myocardial infarction	6	2099	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.44, 0.89]
4 Acute kidney injury	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Short‐term acute kidney injury	2	679	Risk Ratio (M‐H, Fixed, 95% CI)	0.50 [0.14, 1.81]
4.2 Long‐term acute kidney injury	1	296	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.14, 6.82]
5 Stroke	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 Short‐term stroke	1	465	Risk Ratio (M‐H, Fixed, 95% CI)	4.94 [0.24, 102.26]
5.2 Long‐term stroke	2	510	Risk Ratio (M‐H, Fixed, 95% CI)	0.45 [0.10, 2.01]
6 Bleeding	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 Short‐term bleeding	3	1213	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.53, 1.86]
6.2 Long‐term bleeding	2	923	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.45, 1.41]