Politi 2009.
| Methods | RCT. Number of study centres: not described. |
|
| Participants |
Inclusion criteria: people with prolonged (> 30 minutes) chest pain, started < 12 hours before hospital arrival and ST elevation of ≥ 1 mm in ≥ 2 contiguous limb electrocardiographic leads or 2 mm in precordial leads. Exclusion criteria: cardiogenic shock at presentation (systolic blood pressure ≤ 90 mmHg despite drug therapy), left main coronary disease (≥ 50% diameter stenosis), previous CABG surgery, severe valvular heart disease, and unsuccessful procedures. Diagnostic criteria MVD: stenosis of ≥ 2 epicardial coronary arteries or their major branches by visual estimation. Significant stenosis: > 70% diameter. Sample size: complete revascularisation n = 130 (65 staged and 65 at index procedure complete revascularisation) and culprit‐only revascularisation n = 84. |
|
| Interventions |
Complete revascularisation: revascularisation of all, culprit and non‐culprit significant stenosis at the index procedure or staged. Culprit‐only revascularisation: intervention on the culprit vessel only. |
|
| Outcomes |
Primary: MACE, cardiac or non‐cardiac death, in‐hospital death, re‐infarction, re‐hospitalisation for acute coronary syndrome, and revascularisation. Secondary: not mentioned. |
|
| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Randomisation was performed with a computer program. |
| Allocation concealment (selection bias) | Unclear risk | Lack of information regarding how the allocation was concealed. |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not mentioned in the article. |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not mentioned in the article. |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Dropouts were not reported in the article. |
| Selective reporting (reporting bias) | High risk | Study did not have a published protocol and was not registered on any clinical trial databases. |
| Other bias | Unclear risk | Unclear source of funding. |