Zhang 2015.
| Methods | RCT. Randomisation ratio: 1:1. Number of study centres: not mentioned in the study. |
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| Participants |
Inclusion criteria: people with STEMI, non‐culprit artery(ies) with significant stenosis, blood vessel > 2.5 mm and suitable for PCI. Exclusion criteria: cardiogenic shock, CABG, undetermined culprit vessel, person refused PCI, non‐culprit vessel occlusion is chronic, blood vessel diameter < 2.5 mm, lesions non‐suitable for PCI, non‐culprit vessel stenosis > 90%. Diagnostic criteria MVD: non‐culprit vessel significant stenosis. Significant stenosis: between 75% and 90%. Sample size: complete revascularisation n = 215 and culprit‐only revascularisation n = 213. |
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| Interventions |
Complete revascularisation: PCI of the culprit vessel and staged intervention for the non‐culprit lesions between days 7 and 10 after the index procedure. Culprit‐only revascularisation: PCI of culprit vessel only and intervention on non‐culprit vessels was performed if participant had evidence of ischaemia (symptoms, ECG changes, or nuclear study consistent with ischaemia). |
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| Outcomes | All‐cause mortality, MACE (MI and cardiac death), hospitalisation due to cardiac reasons (angina, heart failure, re‐hospitalisation for PCI), total hospitalisation time, stent number and hospital cost. | |
| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Not mentioned in the article the method for randomisation. |
| Allocation concealment (selection bias) | Unclear risk | Not mentioned in the article the method for randomisation. |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not mentioned in the article. |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not mentioned in the article. |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Not mentioned in the article. |
| Selective reporting (reporting bias) | High risk | Study did not have a published protocol and was not registered on any clinical trial databases. |
| Other bias | Unclear risk | Unclear source of funding. |
BMS: bare‐metal stent; CABG: coronary artery bypass graft; CCS: Canadian Cardiovascular Society; Cr: creatinine; DES: drug‐eluting stent; ECG: electrocardiogram; EF: ejection fraction; eGFR: estimated glomerular filtration rate; FFR: fractional flow reserve; LBBB: left bundle branch block; MACE: major adverse cardiovascular event; MI: myocardial infarction; MVD: multi‐vessel disease; n: number of participants; non‐IRA: non‐infarct related artery; PCI: percutaneous coronary intervention; P‐PCI: primary percutaneous coronary intervention; RCT: randomised controlled trial; STEMI: ST elevated myocardial infarction; TIMI: Thrombolysis in Myocardial Infarction.