| Methods |
Randomised controlled trial, open‐label |
| Participants |
Patients with neutropenia <1000/mm3 and fever > 38.5 in two measurements, associated with chills. Mean age 34 (16‐75), with any type of cancer |
| Interventions |
Flucloxacillin 2 g x 4 added to one arm
Non‐intervention antibiotics: ceftazidime |
| Outcomes |
Failure
Superinfections
Mortality (all‐cause)
Adverse events |
| Notes |
Empirical design
Single centre, open‐label, the Netherlands. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer‐generated randomisation |
| Allocation concealment (selection bias) |
Low risk |
Consecutive opaque and sealed envelopes were opened |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
Open‐label |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
Open‐label |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
All patients included in mortality and failure analyses |
| Other bias |
Low risk |
Patients randomised only once |
