| Methods |
Open‐label. |
| Participants |
Patients with neutropenia < 1000/mm3 and fever > 38. Mean age 39 (8‐71), with acute leukaemia |
| Interventions |
Teicoplanin 5 mg/kg x 1 added to one arm
Non‐intervention antibiotics: ceftazidime + amikacin |
| Outcomes |
Failure
Adverse events |
| Notes |
Empirical design
Single centre, Italy |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Random permuted blocks |
| Allocation concealment (selection bias) |
Unclear risk |
Consecutive, sealed envelopes (opacity not mentioned) |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
Open‐label |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
Open‐label |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
|
| Other bias |
High risk |
Patients included for different episodes and analysis by episode |
