| Methods |
Randomised controlled trial, double‐blind |
| Participants |
Patients with neutropenia
< 500/mm3 and fever > 38.3. Mean age 40 (19‐63) with acute leukaemia or post autologous bone marrow rescue transplantation |
| Interventions |
Vancomycin 500 mg x 4 added to one arm
Non‐intervention antibiotics: ticarcillin + gentamicin |
| Outcomes |
Failure
Superinfections
Adverse events |
| Notes |
Empirical design
Single centre, USA |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Randomisation by table of random numbers |
| Allocation concealment (selection bias) |
Low risk |
Randomisation concealed centrally within the oncology pharmacy |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
|
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
|
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
|
| Other bias |
Low risk |
Patients included only once |
