| Methods |
Randomised controlled trial, open‐label |
| Participants |
Patients with neutropenia < 1000/mm3 and fever > 38.3
Patients with all types of cancer |
| Interventions |
Cephalothin 3 g x 4 added to one arm
Non‐intervention antibiotics: ticarcillin + tobramycin |
| Outcomes |
Failure
Superinfections
Adverse events |
| Notes |
Empirical design
Single centre, USA |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer‐generated randomisation |
| Allocation concealment (selection bias) |
Low risk |
Randomisation kept in the pharmacy |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
|
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
|
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
|
| Other bias |
High risk |
Patients included for different episodes and analysis by episode |
