Outcome title (End of treatment)	Number of studies /patients	SMD (95% CI); P value	Hetero‐ geneity I2 [%]
Studies without data extracted from figures and or substituted
Pain Negative mood Disability	19/1319 18/1591 14/1162	‐0.27 (‐0.47 to ‐0.08); 0.006 ‐0.34 (‐0.50 to ‐0.17); < 0.0001 ‐0.20 (‐0.65 to 0.05); 0.12	64 55 76
Studies without selection bias
Pain Negative mood Disability	12/966 10/839 10/886	‐0.31(‐0.51 to ‐0.11); 0.002 ‐0.24(‐0.38 to ‐0.11); 0.0005 ‐0.30 (‐0.47 to ‐0.13); 0.004	53 0 31
Studies without attrition bias
Pain Negative mood Disability	11/940 9/828 9/854	‐0.33 (‐0.49 to‐0.16); 0.0001 ‐0.32 (‐0.47 to ‐0.18); <0.0001 ‐0.24 (‐0.43 to ‐0.04); 0.02	33 2 43
Studies without reporting bias
Pain Negative mood  Disability	13/1122 15/1123 14/1072	‐0.30 (‐0.52 to ‐0.08); 0.007 ‐0.38 (‐0.57 to ‐0.19); < 0.0001 ‐0.28 (‐0.53 to ‐0.03); 0.03	67 54 73
Studies with patients with depressive and/or anxiety disorders included
Pain Negative mood Disability	11/836 9/772  9/750	‐0.18 (‐0.38 to  0.03); 0.09 ‐0.34 (‐0.49 to ‐0.18); < 0.0001 ‐0.14 (‐0.37 to  0.09); 0.23	48 9 53
Studies with ≥ 20 patients per treatment arm
Pain Negative mood Disability	17/1299 17/1559 13/1116	‐0.31 (‐0.52 to ‐0.10); 0.04 ‐0.36 (‐0.53 to ‐0.19); < 0.0001 ‐0.32 (‐0.57 to ‐0.07); 0.01	69 59 75