Comparison 5. Sensitivity Analysis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
5.1 Early stopping of trials and total mortality	11	46811	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.74, 0.92]
5.1.1 trials stopped early	3	27245	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.72, 0.96]
5.1.2 trials with no early stop	8	19566	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.69, 0.98]
5.2 Early stopping of trials and total CHD events	14	48066	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.67, 0.80]
5.2.1 trials stopped early	3	27265	Risk Ratio (M‐H, Fixed, 95% CI)	0.68 [0.58, 0.79]
5.2.2 trials with no early stop	11	20801	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.69, 0.84]
5.3 Study Size for total Mortality	11	46811	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.74, 0.92]
5.3.1 Over 1000 participants	6	43754	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.74, 0.92]
5.3.2 Under 1000 participants	5	3057	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.50, 1.82]
5.4 Study Size for total CHD events	14	48066	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.67, 0.80]
5.4.1 Over 1000 participants	6	43597	Risk Ratio (M‐H, Fixed, 95% CI)	0.74 [0.67, 0.80]
5.4.2 Under 1000 participants	8	4469	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.39, 0.90]