| Study characteristics |
| Methods |
Randomised trial 4 x 4 factorial. |
| Participants |
919 participants based in the USA aged 40 ‐ 79 (mean age of 62); 52% men. None with any clinical evidence of CVD. |
| Interventions |
20 mg lovastatin + 1 mg warfarin versus placebo followed up for 34 months. |
| Outcomes |
Carotid atherosclerosis, cholesterol, fatal + non‐fatal CHD events, stroke. |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Blocked randomisation stratified by centre |
| Allocation concealment (selection bias) |
Unclear risk |
Not described |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Carers and patients were blinded |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
ITT, no drop‐outs reported |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Unclear risk |
Funded by pharmaceutical industry |
