Table 2. Features and Performance for Intratumoral Only and Combined Intratumoral and Peritumoral Region Classifiers in Distinguishing HER2+ From Other Receptor Subtypes and Stratifying HER2+ by Molecular Subtype.
| Region | Feature | Signature Performance | ||||
|---|---|---|---|---|---|---|
| Group | Descriptor | Statistic | P Value | AUC (95% CI) | P Value | |
| HER2+ vs HR-Positive, HER2− | ||||||
| Intratumoral | ||||||
| Gabor | Width, 6 px; orientation, 67.5° | Kurtosis | .01 | 0.69 (0.65-0.73) | <.001 | |
| GLCM | Energy | Kurtosis | .10 | |||
| Gabor | Width, 8 px; orientation, 67.5° | Kurtosis | .08 | |||
| Laws | Spot-edge | Median | .007 | |||
| CoLlAGe | Sum average | Skewness | .003 | |||
| Intratumoral and peritumoral | 0.71 (0.67-0.75) | <.001 | ||||
| Tumor | Gabor | Width, 16 px; orientation, 67.5° | Kurtosis | .01 | ||
| Tumor | GLCM | Energy | Kurtosis | .10 | ||
| 9-12 mm | Gabor | Width, 32 px; orientation, 112.5° | Kurtosis | .02 | ||
| Tumor | Laws | Spot-edge | Median | .007 | ||
| Tumor | CoLlAGe | Sum average | Skewness | .003 | ||
| HER2+ vs TN | ||||||
| Intratumoral | 0.73 (0.67-0.79) | .002 | ||||
| Laws | Edge-level | Median | .05 | |||
| Gabor | Width, 8 px; orientation, 45° | Kurtosis | .22 | |||
| Laws | Ripple-ripple | Kurtosis | .06 | |||
| Gabor | Width, 2 px; orientation, 0° | Kurtosis | .16 | |||
| GLCM | Energy | Skewness | .12 | |||
| Intratumoral and peritumoral | 0.80 (0.76-0.84) | <.001 | ||||
| 9-12 mm | Gabor | Width, 4 px; orientation, 90° | SD | <.001 | ||
| Tumor | Gabor | Width, 8 px; orientation, 45° | Kurtosis | .22 | ||
| Tumor | Laws | Edge-level | Median | .05 | ||
| 9-12 mm | Gabor | Width, 4 px; orientation, 67.5° | Mean | <.001 | ||
| 9-12 mm | GLCM | Sum variance | Kurtosis | .49 | ||
| HER2+ vs All | ||||||
| Intratumoral | ||||||
| Gabor | Width, 6 px; orientation,67.5° | Kurtosis | .01 | 0.65 (0.59-0.71) | 0.006 | |
| GLCM | Energy | Kurtosis | .05 | |||
| Gabor | Width, 8 px; orientation, 67.5° | Kurtosis | .05 | |||
| Laws | Spot-edge | Median | .02 | |||
| Gabor | Width, 8 px; orientation, 45° | Kurtosis | .05 | |||
| Intratumoral and peritumoral | ||||||
| Tumor | Gabor | Width, 16 px; orientation, 67.5° | Kurtosis | .01 | 0.71 (0.63-0.79) | <.001 |
| Tumor | GLCM | Energy | Kurtosis | .05 | ||
| 6-9 mm | Laws | Ripple-ripple | Kurtosis | .05 | ||
| Tumor | Laws | Spot-edge | Median | .02 | ||
| 0-3 mm | GLCM | Info2 | Kurtosis | .05 | ||
| HER2-E vs Non–HER2-E | ||||||
| Intratumoral | ||||||
| Gabor | Width, 4 px; orientation, 135° | Kurtosis | .02 | 0.76 (0.69-0.84) | <.001 | |
| Laws | Ripple-ripple | Kurtosis | .02 | |||
| Gabor | Width, 16 px; orientation, 112.5° | Kurtosis | .05 | |||
| Gabor | Width, 16 px; orientation, 45° | Kurtosis | .43 | |||
| CoLlAGe | Energy | Kurtosis | .03 | |||
| Intratumoral and peritumoral | ||||||
| Tumor | Laws | Ripple-Ripple | Kurtosis | .02 | 0.89 (0.84-0.93) | <.001 |
| Tumor | Gabor | Width, 16 px; orientation, 112.5° | Kurtosis | .05 | ||
| 6-9 mm | CoLlAGe | Energy | Kurtosis | .04 | ||
| Tumor | Gabor | Width, 4 px; orientation, 135° | Kurtosis | .02 | ||
| 9-12 mm | CoLlAGe | Inertia | Median | .002 | ||
Abbreviations: AUC, area under the receiver operating characteristic curve; CoLlAGe, co-occurrence of local anisotropic gradient orientation features; GLCM, Gray level co-occurrence matrix features; HER2-E, HER2-enriched; HR, hormone receptor; px, pixels; TN, triple-negative.