NCT01929031.

Methods	Randomised, double‐blind, placebo‐controlled, parallel group study
Participants	Surgical extraction of 3 ‐ 4 impacted third molar(s), with a minimum of two mandibular extractions Age: 18 ‐ 55 years Pain ≥ 5/10 within 4.5 hours of end of surgery N = 561
Interventions	Ibuprofen 400 mg + caffeine 100 mg Ibuprofen 400 mg Caffeine 100 mg Placebo
Outcomes	Time‐weighted sum of pain relief (PAR) and pain intensity difference (PID) from 0 to 8 hours (SPRID0‐8h) 2 hours SPRID Time to rescue Time to meaningful relief
Notes	Completed March 2014 but results not yet available

N: number of participants in study