Summary of findings 3. Dexketoprofen 10 mg‐12.5 mg compared with placebo for acute postoperative pain.

Dexketoprofen 10 mg‐12.5 mg compared with placebo for acute postoperative pain
Patient or population: adults with moderate or severe acute postoperative pain Settings: clinic or hospital Intervention: dexketoprofen 10 mg‐12.5 mg Comparison: placebo
Outcomes	Probable outcome with intervention	Probable outcome with placebo	RR, NNT, NNTp, or NNH (95% CI)	Number of studies, participants, or events	Quality of the evidence (GRADE)	Comments
Participants with ≥ 50% pain relief over 4‐6 hours	440 in 1000	180 in 1000	RR 2.4 (1.8 to 3.3) NNT 3.9 (3.0 to 5.7)	5 studies 480 participants	High quality	Good quality studies, important outcome available, robust numbers.
Median (mean) time to use of rescue medication	3.6 hours (4.9 hours)	1.4 hours (3.6 hours)	Not estimated	1 study 122 participants (3 studies 253 participants)	Very low quality	Small numbers of participants.
Participants using rescue medication over 6 hours	490 in 1000	680 in 1000	RR 0.73 (0.61 to 0.86) NNTp 5.3 (3.5 to 11)	4 studies 373 participants	High quality	Reasonable numbers of participants and high event rate.
Participants with ≥ 1 adverse event following a single dose	68 in 1000	96 in 1000	RR 0.70 (0.36 to 1.4) NNH not calculated	4 studies 380 participants	High quality	Good quality studies, important outcome available, robust numbers.
Participants with a serious adverse event following a single dose	No serious adverse events reported		Not estimated	6 studies 574 participants	Very low quality	No events in single dose studies not designed to evaluate serious but rare adverse events.
CI: confidence interval; NNH: number needed to treat for an additional harmful outcome; NNT: number needed for an additional beneficial outcome; NNTp: number needed to treat to prevent an additional outcome: RR: risk ratio.
We used the following descriptors for levels of evidence (EPOC 2015). High: this research provides a very good indication of the likely effect. The likelihood that the effect will be substantially differenta is low. Moderate: this research provides a good indication of the likely effect. The likelihood that the effect will be substantially differenta is moderate. Low: this research provides some indication of the likely effect. However, the likelihood that it will be substantially differenta is high. Very low: this research does not provide a reliable indication of the likely effect. The likelihood that the effect will be substantially differenta is very high. a Substantially different: a large enough difference that it might affect a decision.