Comparison 4. Ketoprofen 80 mg or 100 mg versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Participants with ≥ 50% pain relief	6	381	Risk Ratio (M‐H, Fixed, 95% CI)	4.29 [3.02, 6.08]
1.1 Dental surgery	4	255	Risk Ratio (M‐H, Fixed, 95% CI)	8.33 [4.67, 14.86]
1.2 Other surgery	2	126	Risk Ratio (M‐H, Fixed, 95% CI)	1.94 [1.26, 3.00]
2 Participants using rescue medication over 6‐8 hours	4	259	Risk Ratio (M‐H, Fixed, 95% CI)	0.54 [0.44, 0.67]
2.1 6 hours	3	163	Risk Ratio (M‐H, Fixed, 95% CI)	0.49 [0.38, 0.65]
2.2 8 hours	1	96	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.44, 0.89]
3 Participants with any adverse event	3	175	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.65, 2.16]