Study ID	Treatment	Adverse events		Withdrawals
		Any	Serious	Adverse event	Other
Akural 2009	(1) Ketoprofen 100 mg, n = 20 (2) Paracetamol 1000 mg, n = 18 (3) Ketoprofen 100 mg + paracetamol 1000 mg, n = 20 (4) Placebo, n = 20	No usable data Nausea within 10 h: (1) 4/20 (3) 4/20 (4) 3/20 4‐6 "unrousable or moderately sedated " participants in each of the 4 treatment arms (n = 18‐20), with the maximum number within 1.5 h from dosing	None	None	4 exclusions due to protocol violations
Arnold 1990	(1) Ketoprofen 25 mg, n = 14 (2) Ketoprofen 100 mg, n = 16 (3) Ibuprofen 400 mg, n = 15 (4) Placebo, n = 14	At 6 h: (1) 3/14 (2) 6/16 (4) 3/14	None	(1) 1/14 (nausea and dizziness after 1 h)	None reported
Balzanelli 1996	(1) Ketoprofen lysine 80 mg, n = 30 (2) Placebo, n = 30	No usable data	None reported	None	None
Cooper 1984	(1) Ketoprofen 25 mg, n = 30 (2) Ketoprofen 50 mg, n = 31 (3) Ketoprofen 100 mg, n = 31 (4) Aspirin 650 mg, n = 31 (5) Placebo, n = 31	At 6 h: (1) 7/30 (2) 10/31 (3) 9/31 (5) 6/30	None	None	Exclusions due to not taking medication, protocol violations and loss to follow‐up: (1) 6 (2) 5 (3) 5 (4) 6 (5) 6
Cooper 1988	(1) Ketoprofen 25 mg, n = 42 (2) Ketoprofen 100 mg, n = 39 (3) Ibuprofen 400 mg, n = 37 (4) Placebo, n = 43	At 6 h: (1) 8/44 (2) 4/39 (4) 7/45	None reported	None reported	20 exclusions: 13 lost to follow‐up and 7 protocol violations
Cooper 1998	(1) Dexketoprofen 25 mg, n = 50 (2) Dexketoprofen 100 mg, n = 51 (3) Paracetamol 1000 mg, n = 50 (4) Placebo, n = 26	At 6 h: (1) 22/50 (2) 16/51 (4) 4/26	None	None	None
Gay 1996	(1) Dexketoprofen 5 mg, n = 41 (2) Dexketoprofen 10 mg, n = 42 (3) Dexketoprofen 20 mg, n = 41 (4) Ibuprofen 400 mg, n = 41 (5) Placebo, n = 41	At 6 h: (1) 3/41 (2) 2/42 (3) 5/41 (5) 4/39	None	None	2 exclusions in placebo group due to early remedication
Harrison 1996	(1) Dexketoprofen 12.5 mg, n = 49 (2) Dexketoprofen 25 mg, n = 46 (3) Placebo, n = 46	At 6 h: (1) 6/49 (2) 7/46 (3) 6/46	None	(1) 0/49 (2) 1/46 (3) 1/46	6 exclusions due to protocol violations
Jackson 2004	(1) Dexketoprofen 25 mg, n = 42 (2) Rofecoxib 50 mg, n = 38 (3) Placebo, n = 43	At 24 h: (1) 5/42 (3) 4/41	None	None	3 participants excluded from analyses: 2 in placebo group lost to follow‐up, 1 in rofecoxib group did not take medication
McGurk 1998	(1) Ketoprofen 50 mg, n = 43 (2) Dexketoprofen 12.5 mg, n = 44 (3) Dexketoprofen 25 mg, n = 41 (4) Dexketoprofen 50 mg, n = 43 (5) Placebo, n = 39	At 6 h: (1) 5/43 (2) 4/41 (3) 4/41 (4) 7/43 (5) 8/39	None	(1) 0/42 (2) 0/44 (3) 0/41 (4) 1/43 (5) 1/39	10 participants excluded from efficacy analyses due to early remedication or loss to follow‐up: (1) 3 (2) 3 (3) 1 (4) 1 (5) 2
McQuay 2016	(1) Dexketoprofen 25 mg, n = 161 (2) Tramadol 100 mg, n = 160 (3) Dexketoprofen 25 mg + tramadol 75 mg, n = 159 (4) Placebo, n = 161	No usable data	None during single dose phase Over 5 days: (1) 1/213 (4 events) (2) 0/212 (3) 1/213 (1 event)	None	(1) 1/161 (withdrawal by subject) (2) 0/160 (3) 0/159 (4) 2/161 (withdrawal by subject, protocol violation)
Mehlisch 1984	(1) Ketoprofen 25 mg, n = 24 (2) Ketoprofen 50 mg, n = 27 (3) Ketoprofen 100 mg, n = 27 (4) Codeine 90 mg, n = 27 (5) Placebo, n = 24	At 6 h: 54 participants in total	None reported	None reported	9 participants received medication but were not included in analysis. Reasons and groups not given.
Moore 2015c	(1) Dexketoprofen 12.5 mg, n = 60 (2) Dexketoprofen 25 mg, n = 61 (3) Tramadol 37.5 mg, n = 59 (4) Tramadol 75 mg, n = 59 (5) Dexketoprofen 12.5 mg + tramadol 37.5 mg, n = 60 (6) Dexketoprofen 12.5 mg + tramadol 75 mg, n = 62 (7) Dexketoprofen 25 mg + tramadol 37.5 mg, n = 63 (8) Dexketoprofen 25 mg + tramadol 75 mg, n = 61 (9) Ibuprofen 400 mg, n = 60 (10) Placebo, n = 62	Within 24 h: (1) 1/60 (2) 3/61 (10) 0/62	(1) 0/60 (2) 0/61 (10) 0/62	(1) 0/60 (2) 0/61 (10) 0/62	(1) 0/60 (2) 0/61 (10) 0/62
Moore 2016	(1) Dexketoprofen 25 mg, n = 151 (2) Tramadol 100 mg, n = 150 (3) Dexketoprofen 25 mg + tramadol 75 mg, n = 152 (4) Placebo, n = 153	No usable data	No usable data	No usable data	No usable data
Olson 1999	(1) Ketoprofen liquid 25 mg, n = 28 (2) Ketoprofen liquid 50 mg, n = 26 (3) Dipyrone liquid 500 mg, n = 27 (4) Placebo, n = 27	No adverse events reported	None	None	None
Olson 2001	(1) Ketoprofen 25 mg, n = 67 (2) Ibuprofen liquigel 400 mg, n = 67 (3) Paracetamol 1000 mg, n = 66 (4) Placebo, n = 39	At 6 h: (1) 5/67 (4) 2/39	None	None	None
Schreiber 1996	(1) Ketoprofen 50 mg, n = 54 (2) Dexketoprofen 12.5 mg, n = 52 (3) Dexketoprofen 25 mg, n = 52 (4) Placebo, n = 55	No single dose data	None	Multiple dose: (1) 0/54 (2) 1/52 (3) 2/52 (4) 1/55	Multiple dose (includes successful therapy): (1) 35/54 (2) 36/52 (3) 35/52 (4) 39/55
Seymour 1996	(1) Ketoprofen 12.5 mg, n = 42 (2) Ketoprofen 25 mg, n = 41 (3) Paracetamol 500 mg, n = 41 (4) Paracetamol 1000 mg, n = 41 (5) Placebo, n = 41	At 6 h: (1) 0/42 (2) 0/41 (5) 0/41	None	None	Exclusions due to early remedication: (1) 2 (3) 1 (4) 1 (5) 2
Seymour 2000	(1) Buffered ketoprofen 12.5 mg, n = 61 (2) Ibuprofen 200 mg, n = 59 (3) Placebo, n = 60	At 6 h: (1) 2/61 (3) 3/60	None	None	Exclusions due to protocol violations: (2) 1 (3) 1
Sunshine 1988	(1) Ketoprofen 50 mg, n = 32 (2) Ketoprofen 150 mg, n = 31 (3) Paracetamol 650 mg + codeine 60 mg, n = 28 (4) Placebo, n = 32	At 6 h: (1) 2/32 (3) 1/32	None	None	None
Sunshine 1993	(1) Ketoprofen 50 mg, n = 48 (2) Ketoprofen 100 mg, n = 48 (3) Paracetamol 650 mg, n = 48 (4) Paracetamol 650 mg + oxycodone 10 mg, n = 48 (5) Placebo, n = 48	No single dose data	"No cases of possible clinical concern" (multiple dose included)	None	None
Sunshine 1998	(1) Ketoprofen 6.25 mg, n = 35 (2) Ketoprofen 12.5 mg, n = 35 (3) Ketoprofen 25 mg, n = 35 (4) Ibuprofen 200 mg, n = 35 (5) Placebo, n = 35	At 6 h: (1) 3/35 (2) 6/35 (3) 3/35 (5) 3/35	None	None	Exclusions due to early remedication, protocol violation: (2) 1 (3) 1 (5) 2
Turek 1988	(1) Ketoprofen 50 mg, n = 41 (2) Ketoprofen 150 mg, n = 39 (3) Paracetamol 650 mg + codeine 60 mg, n = 39 (4) Placebo, n = 42	At 6 h: (1) 14/41 (2) 8/39 (3) 4/41	None	None	1 exclusion in placebo group due to protocol violation.
Vidal 1999	(1) Ketoprofen 50 mg, n = 47 (2) Dexketoprofen 12.5 mg, n = 47 (3) Dexketoprofen 25 mg, n = 47 (4) Placebo, n = 47	No single dose data	None	Multiple dose: (1) 0/43 (2) 1/45 (3) 1/41 (4) 2/43	Multiple dose: (1) 0/43 (2) 2/45 (3) 2/41 (4) 3/43
h: hour.