Balzanelli 1996.

Methods	RCT, DB, 2 parallel groups, multiple dose study. Medication administered when baseline pain was of moderate to severe intensity, then every 8 h for total of 3 days. Pain assessed at 0, 30 min, and 1, 2, 3, 4, 5 ,6, 8 h, then daily.
Participants	Surgical removal of impacted third molars. N = 60. M 37, F 23. Mean age: approximately 37 years.
Interventions	Ketoprofen lysine 80 mg, n = 30. Placebo, n = 30.
Outcomes	PI: 0‐100‐mm VAS. PGE: standard 5‐point scale. AE: any, serious. Withdrawals. Tolerability 4‐point scale at end of study.
Notes	Oxford Quality Score: R1, DB2, W1.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method not reported.
Allocation concealment (selection bias)	Unclear risk	Method not reported.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	"placebo indistinguishable".
Blinding of outcome assessment (detection bias) All outcomes	Low risk	"placebo indistinguishable".
Size	High risk	< 50 participants per treatment arm.