McGurk 1998.

Methods	RCT, DB, single oral dose, 5 parallel groups. Medication administered when baseline pain was of moderate to severe intensity. Pain assessed at 0, 10, 20, 30, 45, 60, 90 min, and 2, 3, 4, 5, 6 h.
Participants	Surgical removal of impacted third molars. N = 210 (200 in efficacy analysis). M 88, F 122. Mean age: 28 years.
Interventions	Dexketoprofen trometamol 12.5 mg, n = 44. Dexketoprofen trometamol 25 mg, n = 41. Dexketoprofen trometamol 50 mg, n = 43. Ketoprofen 50 mg (racemic), n = 43. Placebo, n = 39.
Outcomes	PI: 100‐mm VAS and standard 4‐point scale. PR: standard 5‐point scale. PGE: non‐standard 4‐point scale. Number using rescue medication. AEs: any, serious. Withdrawals.
Notes	Oxford Quality Score: R2, DB2, W1. 12‐h analgesic and anti‐inflammatory washout before surgery. Rescue medication permitted after 1 h.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"randomization list generated by a computer program in blocks of five patients".
Allocation concealment (selection bias)	Unclear risk	Method not described.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	"tablets of identical appearance to ensure double‐blind conditions".
Blinding of outcome assessment (detection bias) All outcomes	Low risk	"tablets of identical appearance to ensure double‐blind conditions".
Size	High risk	< 50 participants per treatment arm.