Hanning 1993.

Study characteristics
Methods	Random allocation using sealed envelopes. Parallel design, no intention‐to‐treat analysis. Duration: 6 months. Location: single centre in Canada.
Participants	20 children with CF and mild to moderate lung disease, aged 7 ‐ 15 years. Lung function (FEV₁ % predicted) (mean (SD)): control group 84.2% (26.3); supplemented group 101.4% (19.4). % WFH (mean (SD)); control group 95.6% (12.1); supplement group 92.8% (11.3). 20 randomised (12 males), 16 (10 males) studied.
Interventions	Dietary supplements, drink powders, milk shakes, tinned puddings to achieve 25% of normal energy recommendations in addition to normal diet. No intervention in control groups.
Outcomes	Skeletal muscle strength and power Pulmonary function* and respiratory muscle strength Height*, weight* and anthropometric measurements* Habitual physical activity Body composition Dietary energy* and nutrient intake* Energy* and nutrient* intake from supplements Laboratory measures of nutritional status (e.g. albumin, amino acids)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random allocation using based on a table of random numbers.
Allocation concealment (selection bias)	Low risk	Used sealed envelopes.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Investigators performing skeletal and lung muscle‐function tests and anthropometry were unaware of the participant's study group.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No ITT analysis. 20 randomised, 16 studied. Four participants did not complete the trial because they found the time demands for testing or the travelling distance to be excessive.
Selective reporting (reporting bias)	Unclear risk	No adverse events reported; not clear if no events occurred or if not reported.
Other bias	High risk	The treated group appeared to be in better clinical condition at baseline.