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. 2017 May 11;2017(5):CD001159. doi: 10.1002/14651858.CD001159.pub2

Kullenberg 2004.

Methods RCT
Setting: Sweden
Funding: no conflict of interest declared, classified as departmental resources
Participants Orthopaedic hospital in Sweden
 80 participants with a hip fracture
 Mean age: 82 years (range not stated)
 Percentage female: 64%
 Lost to follow‐up: not stated
Excluded: inability to rate their pain
Interventions Treatment group: femoral nerve block inserted at the time of admission with 30 mL ropivacaine (7.5 mg/mL) (n = 40). Mean bock duration 15.8 ± 5.6 hours. Four participants had their block during transportation to the hospital. The block was repeated for 3 participants owing to a long delay before surgery (23.9 hours, 26.3 hours and 30.9 hours)
Control group: no injection (n = 40)
Outcomes Confusion (Pfeiffer test, graded according to a 4‐degree scale (0‐3: no, light, moderate and pronounced confusion) at 48 hours
Time to first mobilization
Pressure sores
Opioids used per 24 hours
Notes Length of follow‐up: length of acute hospital stay (mean 11 days)
No complication related to the nerve block
All participants indicated that they would consider a new future blockade if this would be necessary
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Use of sealed envelopes
Allocation concealment (selection bias) Low risk Use of sealed envelopes
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Not mentioned
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not mentioned
Incomplete outcome data (attrition bias) 
 All outcomes Low risk None lost to follow‐up
Five failed blocks; participants kept in their treatment groups
Selective reporting (reporting bias) Low risk All measurements mentioned in methods section given in results section
Other bias Unclear risk Groups well balanced except for a longer delay in arrival to surgery for the block group (15.5 hours vs 5.8 hours)