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. 2017 May 11;2017(5):CD001159. doi: 10.1002/14651858.CD001159.pub2

Spansberg 1996.

Methods RCT
Approved by the ethics committee and informed consents obtained
Setting: Denmark
Funding: unspecified
Participants 20 participants with a hip fracture surgically treated
 Mean age: 81 years (range 58‐91)
 Percentage female: unclear
 Lost to follow‐up: none
Interventions All participants had spinal anaesthesia with 3.5 mL 0.5% bupivacaine
 Postoperatively, participants received:
 Treatment group: femoral nerve block with 0.4 mL/kg bolus of 0.5% bupivacaine, then infusion of 0.14 mL/kg/h 0.25% bupivacaine for 16 hours (n = 10)
Control group: saline infusion for 16 hours of same volume of fluid (control) (n = 10)
Regular aspirin administration and IM morphine on demand
Outcomes Opioids used during first 18 hours after surgery
No haematomas at the site of femoral catheters. Length of follow‐up unspecified
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomized by a computer after surgery
Allocation concealment (selection bias) Low risk Adequate
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Placebo‐controlled study: participants, recovery staff and observers were blind to the solution used
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Placebo‐controlled study: participants, recovery staff and observers were blind to the solution used
Incomplete outcome data (attrition bias) 
 All outcomes Low risk None lost to follow‐up
Nine of 10 participants receiving bupivacaine were analgesic to pin prick in the distribution of all 3 nerves. The other participant was analgesic only in the distribution of the lateral femoral cutaneous nerve of the thigh
Selective reporting (reporting bias) Low risk All measurements mentioned in methods section given in results section
Other bias Low risk Groups well balanced