| Methods |
Double‐blinded RCT |
| Participants |
75 people (aged 16 to 64 years) with common cold and concomitant non‐purulent tracheobronchitis and no evidence of sinusitis, pharyngitis, purulent bronchitis, or pneumonia. Mean duration of illness 3 days |
| Interventions |
Amoxicillin‐clavulanic acid (375 mg 3 times a day for 5 days) versus identical‐looking placebo. Participants re‐evaluated on days 5 to 7. |
| Outcomes |
Persistent or worse symptoms versus cure at follow‐up |
| Notes |
These were unpublished data about a subgroup of patients in a study of people with common cold; total number of participants in study was 307. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not reported |
| Allocation concealment (selection bias) |
Low risk |
|
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
|
| Blinding (performance bias and detection bias) |
Low risk |
|
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
Not reported |
| Selective reporting (reporting bias) |
Unclear risk |
Not reported |
| Other bias |
Low risk |
|
