| Methods |
RCT |
| Participants |
2061 people aged 18 years or older presenting with lower respiratory tract infection with cough duration fewer than 28 days |
| Interventions |
Amoxicillin 1 g 3 times daily for 7 days |
| Outcomes |
Duration of symptoms rated as moderately bad or worsening; mean symptom severity on days 2 to 4; proportion with symptoms resolved on day 7; new or worsening symptoms presenting clinically to general practitioners; and adverse effects |
| Notes |
Adequately powered for subgroup analysis of participants aged over 60 (n = 595) |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
|
| Allocation concealment (selection bias) |
Low risk |
|
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Clinicians, participants, and outcome assessors all blinded. |
| Blinding (performance bias and detection bias) |
Low risk |
|
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
88% follow‐up in both intervention and control groups |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
