Date	Event	Description
4 May 2017	New search has been performed	A search of the Cystic Fibrosis and Genetic Disorders Trials Register identified seven new references which were additional references to two previously excluded studies (Waters 2010; Wainwright 2011). A summary of findings table has been added to the review.
4 May 2017	New citation required but conclusions have not changed	No new data have been added to the review and our conclusions remain the same.
10 August 2015	New search has been performed	The only trial listed in Included studies in the review was published in 2005, and we have not identified any further relevant trials up to July 2015. We will continue to run searches to identify any potentially relevant trials; however, we do not plan to update other sections of the review until new trials are published. A search of the Cystic Fibrosis and Genetic Disorders Group's Cystic Fibrosis Trials Register did not identify any new potentially relevant references for inclusion in this review.
10 August 2015	New citation required but conclusions have not changed	No new trials have been included in the review, therefore our conclusions remain the same.
8 July 2013	Review declared as stable	The only trial listed in Included studies in the review was published in 2005, and we have not identified any further relevant trials up to September 2011; although in July 2013 the full paper to an already excluded trial was published and the reference has now been added. We therefore do not plan to update this review until new trials are published, although we will search the Group's Cystic Fibrosis Trials Register on a two‐yearly cycle.
28 September 2011	New search has been performed	A search of the Group's Cystic Fibrosis Register identified six references to three studies. Four of these were additional references to an already excluded study (Oermann 2013) and the other two references have also been excluded (Moskowitz 2011; Waters 2010).
28 September 2011	Review declared as stable	The only trial listed in Included studies in the review was published in 2005, and we have not identified any further relevant trials up to September 2011. We therefore do not plan to update this review until new trials are published, although we will search the Group's Cystic Fibrosis Trials Register on a two‐yearly cycle.
1 December 2009	New search has been performed	A search of the Group's Cystic Fibrosis Register identified two new references; one was an additional reference to an already included study (Aaron 2005) and the other study was excluded (Oermann 2013). A search of www.clinicaltrials.gov did not identify any new references.
8 May 2008	Amended	Converted to new review format.