Comparison 1. High frequency US vs no US.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Proportion of ulcers completely healed at 3 weeks	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
2 Proportion of ulcers completely healed at 7 or 8 weeks	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Losses as unhealed	6	678	Risk Ratio (M‐H, Random, 95% CI)	1.21 [0.86, 1.71]
2.2 Complete case analysis	6	627	Risk Ratio (M‐H, Random, 95% CI)	1.21 [0.88, 1.67]
3 Proportion of ulcers completely healed at 12 weeks	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Losses as unhealed	3	489	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [0.92, 1.73]
3.2 Complete case analysis	3	451	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [0.89, 1.62]
4 Proportion of ulcers completely healed at 12 months (nurse‐reported data)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5 HRQoL: 12‐week SF‐12 Physical Component Score	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
6 HRQoL: 12‐week SF‐12 Mental Component Score	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
7 HRQoL: 12‐month SF‐12 Physical Component Score	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
8 HRQoL: 12‐month SF‐12 Mental Component Score	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
9 Non‐serious and serious adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9.1 Non‐serious adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
9.2 Serious adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]