D. Risk of bias assessment
		YES	NO	Unclear
Study size	Was a power calculation performed and adhered?
Selection bias	Was the allocation sequence adequately generated?
	Was the patient allocation concealment adequate?
Detection bias	Was the length of follow‐up long enough to detect stated outcomes?
	Was the investigator (performer of hormone administration) blinded?
	Was the outcome assessor blinded?
	Were the participants blinded?
Attrition bias	Was loss to follow‐up accounted for?
	Was an intention‐to‐treat analysis performed?
Reporting bias	Where there any suggestions of selective report of outcome?
Source of funding	Is the source of funding stated?
Remarks: