2. Case definition for periodontal disease.

Study ID	Case definition
Jeffcoat 2003; Offenbacher 2009	≥ 3 sites with CAL ≥ 3 mm
López 2002; Oliveira 2011; Sadatmansouri 2006	≥ 4 teeth with ≥ 1 sites with PD ≥ 4 mm and with CAL ≥ 3 mm
Farrell 2003	≥ 6 sites with ≥ 5 mm probing depth and ≥ 3 sites with ≥ 3 mm loss of periodontal attachment
Herrera 2009	AAP criteria ‐ PPD up to 6 mm with CAL up to 4 mm
López 2005	Gingival inflammation with over ≥ 25% of sites with BOP and no sites with CAL > 2 mm
Macones 2010	Attachment loss ≥ 3 mm on ≥ 3 teeth
Michalowicz 2006	≥ 4 teeth with ≥ 1 sites with PD ≥ 4 mm and with CAL ≥ 2 mm
Newnham 2009	PPD ≥ 4 mm at ≥ 12 probing sites in fully erupted teeth
Offenbacher 2006	≥ 2 sites measuring ≥ 5 mm probing depths plus periodontal attachment loss of 1‐2 mm at ≥ 1 sites with probing depths ≥ 5 mm
Pirie 2013	≥ 4 sites with PD ≥ 4 mm and ≥ 4 sites with CAL ≥ 4 mm
Radnai 2009	Chronic: ≥ 4 mm probing depth, at least 1 site, and BOP for ≥ 50% of teeth
Tarannum 2007	≥ 2 mm attachment loss at ≥ 50% of examined sites

AAP = American Academy of Periodontology; BOP = bleeding on probing; CAL = clinical attachment level; PD = pocket depth; PPD = periodontal pocket depth.