5. Additional periodontal outcome measures.
| Study ID | Outcome | Periodontal treatment | Number of participants | Alternative periodontal/no treatment | Number of participants | P value |
| López 2002 | % sites with PD 4‐6 mm (mean ± SD) | 2.9 ± 3.9 | 163 | 27 ± 14 | 188 | 0.001 |
| % sites with CAL ≥ 3 mm (mean ± SD) | 6.1 ± 7.8 | 163 | 25.4 ± 17.2 | 188 | 0.001 | |
| López 2005 | % sites with PD > 4 mm (mean ± SD) | 1.8 ± 2.9 | 573 | 14.5 ± 2.8 | 287 | 0.0001 |
| Michalowicz 2006 | Change PD at sites initially 4‐6 mm (mean ± SE) | 0.38 ± 0.02 | 405 | 0.88 ± 0.02 | 407 | < 0.001 |
| Change PD at sites initially ≥ 7 mm (mean ± SE) | 1.07 ± 0.14 | 405 | 1.84 ± 0.14 | 407 | < 0.001 | |
| Change % sites with CAL ≥ 2 mm (mean ± SD) | 0.84 ± 0.85 | 405 | 9.72 ± 0.87 | 407 | < 0.001 | |
| Newnham 2009 | % sites with PD > 4 mm (median (IQR)) | 3.3 (1.2‐7) | 354 | Not reported | Not reported | < 0.001 |
| % sites BOP (median (IQR)) | 28.7 (17.9‐42.5) | 354 | Not reported | Not reported | < 0.001 | |
| Offenbacher 2006 | Extent of PD ≥ 4 mm (mean ± SE) | 13.7 ± 1.5 | 25 | 10.5 ± 1.2 | 28 | < 0.0001 |
| PI ≥ 1 (mean ± SE) | 67.8 ± 5.6 | 25 | 87 ± 5.3 | 28 | 0.02 | |
| Offenbacher 2009 | Change PD at sites initially ≥ 4 mm (mean ± SD) | 1.47 ± 0.574 | 689 | 7.81 ± 0.559 | 728 | Not reported |
| Oliveira 2011 | Sites with PD ≥ 4 mm (% (95% CI)) | 1.19 (1‐1.39) | 113 | 6.36 (5.92‐6.81) | 112 | < 0.0001 |
| Sites with CAL ≥ 3 mm (% (95% CI)) | 5.72 (5.3‐6.14) | 113 | 6.58 (6.13‐7.03) | 112 | 0.0069 | |
| Pirie 2013 | Number of sites PD ≥ 4 mm (median (IQR)) | 10 (6‐22) | 45 | Not reported | 45 | Not reported |
| Number of sites PD ≥ 5 mm (median (IQR)) | 1 (0‐4) | 45 | Not reported | 45 | Not reported | |
| Number of sites AL ≥ 4 mm (median (IQR)) | 10 (5‐19) | 45 | Not reported | 45 | Not reported | |
| Number of sites AL ≥ 5 mm (median (IQR)) | 0 (0‐2) | 45 | Not reported | 45 | Not reported | |
| Number of sites plaque present (median (IQR)) | 57 (40‐82.5) | 45 | Not reported | 45 | Not reported | |
| Number of sites BOP present (median (IQR)) | 78 (63.5‐90) | 45 | Not reported | 45 | Not reported | |
| % of sites plaque present | 37 (28‐54.8) | 45 | Not reported | 45 | Not reported | |
| % of sites BOP present | 50 (42.9‐54.1) | 45 | Not reported | 45 | Not reported | |
| % of sites PD ≥ 4 mm | 78 (63.5‐90) | 45 | Not reported | 45 | Not reported | |
| Sadatmansouri 2006 | % sites with PD 4 mm (mean ± SD) | 53.31 ± 18.5 | 15 | 68.6 ± 20.2 | 15 | 0.04 |
| % sites with CAL 3 mm (mean ± SD) | 41.4 ± 18.4 | 15 | 67.1 ± 15.6 | 15 | 0.000 |
AL = attachment loss; BOP = bleeding on probing; CAL = clinical attachment level; IQR = interquartile range; PD = probing depth; PPD = periodontal pocket depth; SD = standard deviation; SE = standard error.