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. 2017 Jun 6;2017(6):CD008645. doi: 10.1002/14651858.CD008645.pub3

for the main comparison.

Smokefree Class Competitions (SFC) for preventing smoking uptake
Patient or population: Children and adolescents aged 5 ‐ 18 years who were non‐smokers at baseline
Settings: Schools in Germany, the Netherlands, Finland, Switzerland, Canada and the United States
Intervention: Participation in SFC
Comparison: No participation in SFC
Outcomes Illustrative comparative risks* (95% CI) Relative effect
 (95% CI) No of Participants
Actual number/
effective number2
 (studies)
Quality of the evidence
 (GRADE)
Assumed risk1 Corresponding risk
Smoking uptake at longest follow‐up (RCTS) 317 per 1000 320 per 1000 RR 1.00 (0.84 to 1.19) 3056/1108
(3)
Low3, 4
Smoking uptake at longest follow‐up
(Non‐RCTs)
158 per 1000 132 per 1000 RR 0.82 (0.63 to 1.08) 4219/1377
(3)
Very low3, 5, 6
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 CI: Confidence interval; RR: Risk Ratio; RCT: Randomised Controlled Trial
GRADE Working Group grades of evidence
 High quality: Further research is very unlikely to change our confidence in the estimate of effect.
 Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
 Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
 Very low quality: We are very uncertain about the estimate.

1'Assumed risk' calculated as risk in control groups.
 2Adjusted for clustering.
 3Downgraded one level due to imprecision. All studies included had a wide confidence interval.
 4Downgraded one level due to risk of bias. 2/3 studies judged to be at high risk of attrition bias.
 5Downgraded one level due to observational (non‐RCT) study type.
 6Downgraded one level due to risk of bias. 2/3 studies judged to be at high risk of selection bias, most other bias risks unclear.