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| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Moderate improvement | 4 | 263 | Risk Difference (M‐H, Fixed, 95% CI) | 0.27 [0.16, 0.38] |
| 2 Substantial improvement | 3 | 177 | Risk Difference (M‐H, Fixed, 95% CI) | 0.15 [‐0.02, 0.32] |
| 3 All‐cause withdrawal | 4 | 289 | Risk Difference (M‐H, Fixed, 95% CI) | 0.04 [‐0.04, 0.12] |
