8. Quality of evidence ‐ GRADE assessment: AE intervention versus another AE intervention.
Quality assessment | Number of participants | Quality | Importance | |||||||
Number of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | AE intervention | AE control | ||
HRQL, 0‐100, lower is best | ||||||||||
2 | Randomized trial | Seriousa | Not serious | Not serious | Seriousb | Studies not pooled | 79 | 83 | ⊕⊕⊝⊝ low | CRITICAL |
Pain intensity, 0‐100, lower is best | ||||||||||
3 | Randomized trial | Seriousb | Not serious | Not serious | Seriousc | Studies not pooled | 117 | 121 | ⊕⊕⊝⊝ low | CRITICAL |
Fatigue, 0‐100, lower is best | ||||||||||
2 | Randomized trial | Seriousa | Not serious | Not serious | Seriousb | Studies not pooled | 79 | 83 | ⊕⊕⊝⊝ low | IMPORTANT |
Stiffness, 0‐100, lower is best | ||||||||||
1 | Randomized trial | Seriousa | Not serious | Not serious | Seriousb | One study | 51 | 56 | ⊕⊝⊝⊝ very low | IMPORTANT |
Physical function, 0‐100, lower is best | ||||||||||
2 | Randomized trial | Seriousa | Seriousd | Not serious | Seriousb | 80 | 84 | ⊕⊝⊝⊝ very low | IMPORTANT | |
All‐cause withdrawals | ||||||||||
2 | Randomized trial | Seriousa | Not serious | Not serious | Seriousb | 20/85 (23.5%) | 25/89 (28.1%) | ⊕⊕⊝⊝ low | IMPORTANT | |
Adverse events: not reported |
aIssues of detection and performance bias
bIssues related to selection, detection, performance, and other risk of bias
cWide confidence intervals, number of participants less than 400 rule of thumb
dInterventions not similar across studies
AE: aerobic exercise; HRQL: health‐related quality of life