Comparison 1. AE versus control (end of intervention).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 HRQL, FIQ Total, 0‐100, lower is best	5	372	Mean Difference (IV, Random, 95% CI)	‐7.89 [‐13.23, ‐2.55]
1.1 Met ACSM	3	253	Mean Difference (IV, Random, 95% CI)	‐8.66 [‐17.77, 0.44]
1.2 Did not meet ACSM	2	119	Mean Difference (IV, Random, 95% CI)	‐6.77 [‐12.97, ‐0.57]
2 HRQL, sensitivity.selection bias	3	246	Mean Difference (IV, Random, 95% CI)	‐10.47 [‐20.79, ‐0.15]
3 Pain, intensity, 0‐100, lower is best	6	351	Mean Difference (IV, Random, 95% CI)	‐11.06 [‐18.34, ‐3.77]
3.1 Met ACSM	2	203	Mean Difference (IV, Random, 95% CI)	‐5.89 [‐18.72, 6.95]
3.2 Did not meet ACSM	4	148	Mean Difference (IV, Random, 95% CI)	‐14.90 [‐21.36, ‐8.44]
4 Pain, sensitivity.selection bias	3	246	Mean Difference (IV, Random, 95% CI)	‐8.38 [‐17.88, 1.12]
5 Pain, sensitivity, attrition bias	5	326	Mean Difference (IV, Random, 95% CI)	‐11.71 [‐19.93, ‐3.50]
5.1 New subgroup	5	326	Mean Difference (IV, Random, 95% CI)	‐11.71 [‐19.93, ‐3.50]
6 Fatigue, 0‐100 mm, lower is best	4	286	Mean Difference (IV, Random, 95% CI)	‐6.06 [‐12.41, 0.30]
7 Stiffness, 0‐100 mm, lower is best	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
8 Physical Ftn, 0‐100 mm, lower is best	3	246	Mean Difference (IV, Random, 95% CI)	‐10.16 [‐15.39, ‐4.94]
9 Withdrawals	8	456	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.89, 1.77]
10 CR max, VO2max, mL/kg/min	1	143	Mean Difference (IV, Random, 95% CI)	1.60 [‐0.06, 3.26]
11 CR submax, 6MWT (distance ‐ meters, higher is best)	3	169	Mean Difference (IV, Random, 95% CI)	55.58 [27.20, 83.96]