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. 2017 Jun 21;2017(6):CD012700. doi: 10.1002/14651858.CD012700

Mendonca 2016.

Methods 3 groups: aerobic exercise training and active transcranial direct current stimulation (tDCS) intervention; aerobic exercise and placebo tDCS; placebo AE and tDCS
Length: 8 weeks; follow‐up conducted 1 month (T3) and 2 months (T4) after the end of the intervention period
Study design: randomized clinical trial with parallel groups
Participants Female:Male: 44:1
Age (years (SD)): 44.5 (14), 48 (11.8), 49.9 (10.6)
Inclusion: completed high school and age between 18 and 65 years
Exclusion: on medication for pain control for less than 2 months; had been treated for depression for less than 2 months; had epilepsy, psychiatric disorder, or any recent episode of neurological disorder, such as idiopathic syncope; pregnant and infant‐aged; had metallic implants in the brain; using illicit drugs; had been undergoing some type of physical treatment for less than 2 months
Duration of illness (years (SD)): proxy ‐ pain duration (months (SD)): 140.6 (72.2); 149.3 (111.1); 125.6 (100.2)
Interventions Participants were divided into 3 intervention groups: tDCS/AE, which received active intervention of aerobic exercise training and active tDCS intervention; AE, which received active intervention of aerobic exercise and placebo tDCS; and tDCS, which received placebo AE and active intervention for tDCS
Outcomes Intensity of pain, level of anxiety, quality of life, mood, pressure pain threshold, and cortical plasticity, as indexed by transcranial magnetic stimulation. All variables were measured 1 week before the beginning of the intervention (baseline), after the intervention period (T2), and during periods of follow‐up conducted 1 month (T3) and 2 months (T4) after the end of the intervention period
Notes Country: Brazil
Language: English
Study author contacted: not yet
Funding source/declaration of interest: not assessed yet
Trial registry: not assessed yet