Bonkovsky 1991a.

Methods	Randomised clinical trial, USA
Participants	39 hospitalised adults with alcoholic hepatitis due to 1. prolonged ethanol intake; 2. laboratory studies; 3. time of cessation of alcohol intake 5 ‐ 14 days before entry to the study, at nutritional risk according to the trialist Male:Female = 19:20 Mean age = 42 years Exclusion criteria: recent severe gastro‐intestinal bleeding, severe ascites, severe degree of encephalophathy, renal insufficiency, acute pancreatitis, haemodynamic instability, advanced pulmonary disease, diabetes mellitus, active malignancy
Interventions	The trial consisted of 4 groups. Groups 1 and 3, and groups 2 and 4 could be compared. Experimental group: parenteral nutritional supplementation 2 L (3.5 amino acids, 5% dextrose) for 21 days(n = 9) Control group: no intervention(n = 12) Co‐intervention: standard therapy (nutritionally adequate diets) in all groups and Oxandrolone in groups 2 and 4
Outcomes	Laboratory measurements, complications
Study dates	August 1986 to November 1988
Notes	We here report group 1 (control) versus group 3 (experimental).
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random‐numbers table
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	Data were reported for all participants for all outcomes.
Selective reporting (reporting bias)	Unclear risk	No protocol could be obtained, and the trial did not report on serious adverse events or mortality.
For‐profit bias	High risk	The trial was funded by Miles Laboratories.
Other bias	Low risk	The trial appeared to be free of other components that could put it at risk of bias.