Chourdakis 2012.
Methods | Randomised clinical trial, Greece | |
Participants | 59 hospitalised adults admitted to the ICU, at nutritional risk due to being at the ICU Male:Female = 47:12 Mean age = 34.7 Exclusion criteria: Age < 18 or ≥ 70 years, GCS score ≤ 9, obesity (≥ 30 BMI), pregnancy, lactation, had received corticosteroids or thyroidal hormones or both during the previous month, any of the following conditions: Heart failure, respiratory problems, metabolic syndrome, immunodeficiency, diabetes, neurological problems, internal bleeding, indication for TPN, delay of admission to ICU > 24 hrs from injury |
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Interventions | Experimental group: early (within 24 – 48 hrs) enteral feeding (EEF) In the EEF group, enteral feeding was established through the nasogastric tube and feeding began within 24 – 48 hrs from admission to the ICU. The initial administration rate was 30 mL/hr, and the rate reached 80 – 100 mL/hr within 48 hrs by subsequently increasing by 10 mL/hr every 4 – 6 hrs. (n = 34) Control group: Standard delayed enteral feeding (DEF): DEF was initiated when gastroparesis was resolved (> 48 hrs) but no later than 5 days after admission to the ICU, and the goal for the administration rate was to reach 100% of the needs within 4 days. (n = 25) |
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Outcomes | The administration rate for the prescribed quantity was calculated for < 24 hrs, excessive gastric residue, frequent diarrhoea, ileus, and thrombocytopenia. Complications, mortality, duration of stay in the ICU, hormonal status | |
Study dates | August 2003 to May 2005 | |
Notes | We contacted the authors by email: kouvelas@auth.gr on 5th October 2015. We received no answer. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | High risk | "open‐labelled trial" |
Blinding of outcome assessment (detection bias) All outcomes | High risk | "open‐labelled trial" |
Incomplete outcome data (attrition bias) All outcomes | Low risk | There were complete data for all participants. |
Selective reporting (reporting bias) | Low risk | Mortality and serious adverse events are reported. |
For‐profit bias | Unclear risk | It was unclear how the trial was funded. |
Other bias | Low risk | The trial appeared to be free of other components that could put it at risk of bias. |