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. 2017 May 19;2017(5):CD011598. doi: 10.1002/14651858.CD011598.pub2

Espaulella 2000.

Methods Randomised, placebo‐controlled clinical trial, Spain.
Participants 171 hospitalised adults hospitalised due to hip fracture, at nutritional risk due to being frail elderly
Male:Female = 36:135
Mean age = 82.5 years
Exclusion criteria: Younger than 70, advanced dementia, need for IVN, those with pathological fractures or fractures not due to accidental falls
Interventions Experimental group: Oral supplement of 20g protein and 800 mg calcium for 60 days(n = 85)
Control group: Placebo (n = 86)
Co‐interventions: Normal diet
Outcomes Mortality, complications, functional recovery, use of walking aids
Study dates Not stated
Notes We contacted the authors by email: hguyer@umich.edu. We received no reply.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated in blocks of 4
Allocation concealment (selection bias) Low risk Allocation concealment with sealed envelopes
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk An independent pharmacist assigned the study number, and prepared the appropriate nutritional supplement.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk It was unclear how the outcome assessment was blinded.
Incomplete outcome data (attrition bias) 
 All outcomes High risk The pattern of dropouts was not clearly stated, and exceeded 5%. The trial did not use multiple imputation.
Selective reporting (reporting bias) Unclear risk No protocol could be obtained, and the trial did not report all‐cause mortality or serious adverse events.
For‐profit bias High risk The trial was funded by Clinical Nutrition SA.
Other bias Low risk The trial appeared to be free of other components that could put it at risk of bias.