Heim 1985.

Methods	Randomised clinical trial, Germany
Participants	36 hospitalised adults with advanced colorectal carcinoma, at nutritional risk due to trialist indication Male:Female = 20:16 Mean age = 52 years Exclusion criteria: None stated
Interventions	Experimental group: a standard 10% amino acid solution, 40% dextrose and 10% fat solution over a 10‐day period(n = 18) Control group: No intervention(n = 18) Co‐intervention: chemotherapy
Outcomes	Survival (not usable), side effects of parenteral nutrition
Study dates	Not stated
Notes	We could obtain no contact information for the authors.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	The number of participants with incomplete data was not reported.
Selective reporting (reporting bias)	Low risk	The trial reported survival and side effects.
For‐profit bias	Unclear risk	It was unclear how the trial was funded.
Other bias	Low risk	The trial appeared to be free of other components that could put it at risk of bias.