Holter 1977.
Methods | Randomised clinical trial, USA | |
Participants | 56 hospitalised adults undergoing open abdominal surgery, at nutritional risk due to major surgery Male:Female = not described Exclusion criteria: not described |
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Interventions | Experimental group: parenteral nutrition. TPN began 72 hrs prior to surgery. At the time of surgery participants were receiving 80 cc/hr or approximately 2000 calories/day with approximately 80 g of protein equivalent, either in the form of casein hydrolysate or crystalline amino acids. Hyperalimentation was continued for a 10‐day period postoperatively or until 1500 calories were achieved by oral intake. (n = 30) Control group: Treatment as usual with blood and albumin infusions, as is routine. (n = 26) |
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Outcomes | Mortality, complications, weight, serum albumin levels and time needed to archive full peri‐oral nutrition | |
Study dates | Not stated | |
Notes | We could not find any contact information for the authors. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Participants were randomised from a random‐numbers table. |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not described |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | The number of participants with incomplete data was not reported. |
Selective reporting (reporting bias) | Low risk | No protocol could be obtained, but the trial reported serious adverse events and mortality. |
For‐profit bias | Unclear risk | It was unclear how the trial was funded. |
Other bias | Low risk | The trial appeared to be free of other components that could put it at risk of bias. |