Hsu 2000a.

Methods	Randomised clinical trial, Taiwan
Participants	80 hospitalised adults admitted for colon resection due to colorectal cancer, at nutritional risk due to major surgery Male:Female = 44:36 Mean age = 61.6 years Exclusion criteria: previous gastric resection, previous vagotomy, and active peptic ulcer
Interventions	Experimental group 1: Received enteral nasogastric feeding, started from 500 kcal/day, and if tolerated increased to 1500 kcal/day, as well as Osmolite HN (protein: 4.2 g, fat: 3.5 g, carbohydrate: 13.4 g)/100 kcal (n = 20) Experimental group 2: Received enteral nasogastric feeding, started from 500 kcal/day, and if tolerated increased to 1500 kcal/day, as well as Pulmocare (protein: 4.2 g, fat: 6.1 g, carbohydrate: 7 g)/100 kcal(n = 20) Experimental group 3: Received enteral nasogastric feeding, started from 500 kcal/day, and if tolerated increased to 1500 kcal/day, as well as AlitraQ (protein: 4.2 g, fat: 2 .1 g, carbohydrate: 18.2 g)/100 kcal. (n = 20) Control group: No oral intake for a week(n = 20)
Outcomes	Change of intragastric pH after surgery and change of intragastric pH after tube‐feeding
Study dates	April 1997 to February 1998
Notes	Same trial as Hsu 2000b and Hsu 2000c with the results from experimental group 1 vs control. We contacted the authors on 13th December 2015 by email: tzuchi@ms2.mmh.org.tw. We received no reply.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	The number of participants with incomplete data was not reported.
Selective reporting (reporting bias)	Unclear risk	The trial did not properly describe mortality,or serious adverse events.
For‐profit bias	Unclear risk	It was unclear how the trial was funded.
Other bias	Low risk	The trial appeared to be free of other components that could put it at risk of bias.